The popularity of nicotinamide riboside (NR) supplements is growing as individuals seek ways to support their journey toward healthy aging. NAD+, a vital coenzyme involved in cellular energy production, holds great potential for several health benefits. It helps maintain cellular health, increases energy levels, and promotes brain wellness.

As we age, NAD+ levels naturally decline, leading to decreased cellular energy production and a general decline in overall health. However, studies have shown that supplementation with NR can effectively counteract this age-related decline and improve cellular health.

In addition, NR supplements have been shown to increase energy levels and improve cognitive function. Most importantly, emerging evidence suggests that these supplements may provide a shield against age-related brain damage. Today, we delve into the realm of premium NAD+ boosting supplements and explore their role in promoting cellular health. Stay tuned for more insights.

      Best Product
  ProHealth Image Table PartiQlar Image Table GenuinePurity Image Table
Product ProHealth
Effects More longevity
Protects cells
Better health
More power
Better health
More strenght
Better health
More vitality
Side Effects
✓ NO side effects ✓ NO side effects NO side effects
Content 30 capsules 60 capsules 60 capsules
Dosage 1 capsule 1 capsule 2 capsules
Enough for 30 days 60 days 30 days
Price 39.95 USD
47.99 USD
59.95 USD
Rating ⭐⭐⭐⭐⭐
  Buy now Buy now Buy now

By providing an introduction to the topic and presenting our three top picks for NR supplements, we have conducted extensive research to compile a list of the best NR supplements for 2024. Our article aims to provide you with all the relevant information you need to know about NR to ensure a comprehensive understanding of the subject.

Best Product: GenuinePurity NR

​Test winner #1
GenuinePurity Image
GenuinePurity NR
  • High quality ingredients
  • More vitality & energy
  • Highest bioavailability

GenF20 nicotinamide riboside NR is a highly respected manufacturer specializing in the production of premium NR capsules. Their capsules are notable for being gluten-free, GMO-free, additive-free, preservative-free, soy-free, and dairy-free. Manufactured to strict GMP and U.S. standards, these capsules undergo rigorous third-party laboratory testing at every stage of production. They are also regulated by the FDA to ensure safety and efficacy.

An outstanding feature of NR capsules is their high antioxidant content, which supports healthy NAD+ levels and effectively slows the aging process. In addition to their commitment to quality products, nicotinamide riboside offers rewards and loyalty programs for customers, allowing them to earn redeemable points through referrals or subscription length.

When it comes to pricing, GenF20 NR offers competitive pricing, ranging from $58.95 to $69.95 for their products. With a 500mg bottle priced at $1 per count and a 300mg bottle priced at $2 per count, this product undoubtedly emerges as our top choice in our review process!

Product features:

Manufacturer: GenF20
Pros: Top Ingredients, money back guarantee, highly effective, independently tested
Rating: ⭐⭐⭐⭐⭐

Second Place: PartiQlar

​Second #2
PartiQlar NR image
PartiQlar NR
  • More energy, power and health
  • Improves endurance and strength
  • Good value for money

Step into the extraordinary realm of PartiQlar NR and discover the limitless possibilities that lie ahead. Prepare yourself for a transformative journey full of remarkable experiences and profound benefits. PartiQlar NR is no ordinary product; it serves as a catalyst for positive change and embodies excellence.

Heralding a new era of vitality and wellness, PartiQlar Pure NR exceeds all expectations. This exceptional product is meticulously formulated to increase energy levels, promote rejuvenation, and optimize overall health. With its unparalleled composition, PartiQlar NR stands at the forefront of health supplements, delivering a distinctive blend of efficacy and innovation.

Immerse yourself in the wonders of PartiQlar Pure NR and witness a newfound vitality permeate every facet of your life. Embrace the invigorating sensation as your energy soars and mental clarity sharpens. Say goodbye to exhaustion and embrace a life filled with renewed vitality, productivity and enthusiasm. PartiQlar NR is not just a product; it serves as a gateway to a revitalized version of yourself.

In summary, PartiQlar NR secures second place among the best NR supplements due to its exceptional formulation, innovative approach, and remarkable impact on vitality and overall well-being.

Product features:

Manufacturer: PartiQlar
Pros: Delays aging, boosts energy levels, improves endurance & strenght
Rating: ⭐⭐⭐⭐⭐

Third Place: ProHealth NR

ProHealth NR Image
ProHealth NR
  • Enhances cellular health
  • Supports longevity
  • Promotes heart health & brain

ProHealth, a reputable US company, manufactures its Nicotinamide Riboside & Pterostilbene Capsules locally under strict GMP standards. These high quality capsules each contain 300mg of Nicotinamide Riboside (NR) and 50mg of Pterostilbene to support cellular health and longevity.

The unique combination of NR and pterostilbene works synergistically to increase NAD+ levels in the body, promoting improved energy metabolism and cognitive function. In addition to these powerful ingredients, each capsule is precisely crafted to ensure optimal absorption and efficacy.

For best results, ProHealth recommends taking one capsule daily, with or without food, for a convenient and easy-to-follow supplement regimen. ProHealth offers free shipping within the USA and a subscription service that provides consistent delivery and additional savings for loyal customers.

ProHealth’s Nicotinamide Riboside & Pterostilbene Capsules are available in a 30-capsule bottle, suitable for a one-month supply. The company backs its product with a 30-day satisfaction guarantee, reflecting its commitment to customer satisfaction and product quality.

Product features:

Manufacturer: ProHealth
Pros: High quality ingredients, GMP standards, money back guarantee, subscription service available
Rating: ⭐⭐⭐⭐⭐

Fourth Place: Quicksilver NAD+

Fourth #4
Quicksilver NAD+ Platinum image
Quicksilver NAD+ Platinum
  • More power & energy
  • Very positive customer reviews
  • Tested by third-party laboratories

QuickSilver NAD+ ranks fourth among the best NR supplements, just missing our top three selections. The supplement is regularly tested by third-party laboratories to ensure purity and stability.

What sets QuickSilver NR apart is its unique formulation, which incorporates platinum and special liposomal technology that mimics the transport of NAD+ within the body. This innovative approach ensures that essential components are delivered to the exact locations where they can be efficiently utilized. The supplement’s liquid consistency promotes high absorption, maximizing its effectiveness.

In addition, QuickSilver NR contains vitamin B12, which helps maintain blood and nerve cells, and riboflavin, known for its anti-inflammatory properties and ability to slow the aging process while providing antioxidant benefits.

While QuickSilver NR offers notable features and ingredients, it did not secure a spot in our top three due to factors such as overall customer feedback and its standing compared to other top performing NR supplements.

Product features:

Manufacturer: Quicksilver
Pros: GMO free & vegan friendly. Third-party tested and uses liposome technology. Excellent reviews for this product.
Cons: The products must be refrigerated immediately after purchase and have a no-return policy for unsatisfactory or damaged items.
Rating: ⭐⭐⭐

Fifth Place: OMRE NMN

​Fifth #5
OMRE NMN image
  • More energy, power and agility
  • Good value for money
  • Third-party tested

Omre NMN, while a remarkable NR supplement, secures sixth place in our ranking of the best NR supplements, narrowly missing out on our top three selections. The supplement undergoes rigorous purity and safety testing throughout its manufacturing process, with independent laboratories conducting comprehensive evaluations.

Priced at $4.05 per gram, Omre NR offers a 60-count bottle of 300mg capsules at a discounted price of $42.57 on Amazon, originally priced at $44.80. While Omre offers several discounts and benefits, purchasing in bulk may not always result in savings.

To accommodate different customer preferences and needs, Omre offers multiple pricing and shipping options. Orders over $75 qualify for free shipping, while orders under $75 incur a shipping fee of $4.99 for first class shipping or $12 for FedEx shipping, which guarantees delivery within two days.

Omre takes product quality and safety very seriously, as evidenced by their commitment to extensive testing. By offering a variety of pricing and shipping options, the company strives to accommodate a range of customer preferences.

Overall, while Omre NR offers commendable product quality and diverse options, factors such as pricing and overall customer feedback prevented it from securing a spot in our top three.

Product Features:

Manufacturer: Omre
Pros: The supplement is highly absorbable and free of chemical solvents or artificial additives, 30-day money back guarantee.
Cons: Unfortunately, this product is not available for purchase online, and information regarding third-party testing and results is not currently available.
Rating: ⭐⭐⭐

Sixth Place: Double Wood

Sixth #6
Double Wood image
Double Wood
  • Fast & positive effects
  • Medically tested
  • Natural ingredients

Securing the sixth and final position among the best NR supplements, this product did not make our top three selections. While it is made in the USA with high-quality ingredients and has undergone rigorous third-party lab testing to ensure purity and potency, several factors influenced its placement.

Recommended daily doses of NR typically range from 250 mg to 1500 mg; however, this brand’s products only offer doses ranging from 250 mg to 500 mg. A 250 mg dose can be achieved by taking one 125 mg capsule in the morning and one in the afternoon, or by taking additional 125 mg capsules one to three hours apart for higher doses.

For new customers, a 60-count bottle of 125 mg capsules is priced at $48.95. Returning customers and new subscribers can purchase it at a discounted price of $43.08. While this product offers a viable option for individuals seeking lower dosage ranges, it did not secure a spot in our top three due to factors such as dosage options, overall customer feedback, and competitive alternatives.

Product features:

Manufacturer: Double Wood
Pros: GMO and Gluten Free, Third Party Labs Tested, FDA Regulated
Cons: Not widely available, not affordable
Rating: ⭐⭐⭐

What is NR?

Nicotinamide riboside, commonly known as NR, plays a critical role in our bodies. As a coenzyme, it is intimately involved in the optimal functioning of mitochondria, often referred to as the cellular powerhouses. Increased mitochondrial efficiency translates into improved cellular performance and waste elimination, which affects various bodily systems. The remarkable aspect of NR is its ability to address multiple areas without the need for numerous supplements.

Within the realm of NR stands out. While some supplements contain NR as a primary ingredient, our understanding of NAD+ metabolism suggests that its bioavailability is limited when compared to its precursors. By using these NR precursors instead of NAD+ itself, a greater amount of NAD+ is made available in the body. However, the safest and most effective precursor is controversial. To understand the conversion of vitamin B3 to NAD+ in the body, it is important to understand the function of each precursor.

The Scientific Benefits of NR

If you are looking for a natural approach to improving your skin’s well-being, consider exploring the potential of NR (nicotinamide riboside), a vital vitamin-like compound found in every cell of your body. NAD+ plays a critical role in cellular energy metabolism and provides support for optimal skin function. Let’s take a closer look at the scientifically proven benefits of NR for skin health.

Improve hydration levels
When incorporated into oral supplements or topical treatments, NR helps to increase skin hydration at the surface level, thereby reducing the appearance of wrinkles, fine lines and other signs of aging caused by dehydration. In a study of middle-aged women, those who received NR supplementation experienced significant improvements in skin hydration compared to those who did not receive supplementation.

Immunity Boost Against Skin Infections
Notably, NR has immune-boosting properties that extend to skin health. It helps fight bacterial infections commonly seen in people with acne or specific skin conditions such as oily or dry complexions. In addition, NR’s ability to stimulate cell formation reduces existing inflammation and redness caused by breakouts, providing welcome relief for those prone to such concerns.

Repairing sun damage
NR has been shown to be effective in repairing sun-induced skin damage. Topical application as part of a skin care regimen accelerates the regeneration of skin layers by activating protein molecules known as sirtuins, which regulate gene expression and DNA repair. In addition, NR helps protect against further ultraviolet (UV) exposure by counteracting the free radicals generated when UV radiation interacts with the skin.

Increase collagen production
NR supplementation promotes optimal hydration levels in the skin and stimulates the synthesis of collagen, a protein essential for maintaining smoothness and elasticity over time. Since the body naturally produces less collagen as we age, NR supplementation helps maintain this essential process, preserving a more youthful appearance for longer.

Reducing inflammation and oxidative stress
NR helps reduce inflammation and oxidative stress, two factors that contribute to premature aging, wrinkles and other visible signs of aging skin. Studies suggest that increasing NR levels may protect cells from age-related damage, including that caused by sun exposure and environmental toxins.

Effectiveness of NR Supplements

Clinical studies have provided compelling evidence of the remarkable efficacy of NR supplements. These supplements have demonstrated significant health benefits in humans and other mammals, particularly in the management of age-related conditions. Of the known NR precursors, NMN and NR both share the common goal of increasing NAD+ levels. However, their efficacy and safety profiles differ.

Recent research suggests that while NR can increase NAD+ levels, its stability issues result in its degradation to NAM (nicotinamide), another precursor of NAD+. Prolonged overexpression of NAM has the potential to induce genomic instability, albeit in rare cases. In addition, the conversion of NR to NAD+ requires two additional steps, resulting in a comparatively slower onset of action.

In contrast, NMN has demonstrated safety and tolerability in human and mammalian studies. In particular, doses greater than 1000 mg of NMN have shown no adverse effects while promoting increased expression of longevity genes. In addition, NMN is only one conversion step away from becoming NAD+, requiring less energy and a shorter conversion time.

While some individuals may opt for the more affordable powder form of these supplements, it is important to note that a significant portion of the powder is destroyed by stomach acid and does not enter the bloodstream. For optimal effectiveness, liposomal capsules and sublingual NR supplements are considered the most efficient delivery methods.

Common Ingredients Found in NR Boosters to Improve Skin Health

NR boosters have recently gained considerable attention in the skin care field, but their exact nature and mechanisms remain the subject of ongoing research. This article examines the additional ingredients commonly found in NR boosters and their role in promoting healthier skin.

Green Coffee Bean, derived from unroasted coffee beans, retains chlorogenic acid (CGA), an essential compound with powerful antioxidant properties. CGA helps neutralize free radicals in the body, promoting healthier skin tone, improved metabolism, and better regulation of blood sugar levels. In addition, green coffee beans support metabolic functions by increasing fatty acid oxidation, potentially leading to fat loss and facilitating the attainment of desired body shape.

The presence of caffeine in green coffee beans also provides an energy boost to combat low motivation and fatigue. In addition, CGA’s antioxidant properties make green coffee beans effective in combating cell damage caused by environmental toxins, thus preventing premature signs of aging such as wrinkles, dryness and age spots.

Apigenin 98%, a water-soluble flavone compound derived from various sources such as herbs, vegetables, fruits and chamomile tea, is used as a dietary supplement and cosmetic ingredient for its anti-aging properties. By inhibiting pro-inflammatory pathways and modulating cytokine production, Apigenin-98% reduces cellular damage to skin tissue, thereby counteracting signs of aging such as wrinkles, sagging skin and hyperpigmentation. This ingredient also acts as a powerful antioxidant, fighting free radicals (common culprits of aging) and stimulating collagen production, further enhancing the skin’s youthful appearance. By reducing inflammatory responses and aiding cell regeneration, Apigenin reduces redness and inflammation, helping the skin to heal.

Niacin, also known as vitamin B3, plays a vital role in human biology, aiding in the synthesis of essential compounds such as fatty acids, proteins, hormones and enzymes. Occurring naturally in various food sources such as fish, beef, poultry, mushrooms and multivitamins, niacin shows commendable benefits when applied topically. It shields the skin from environmental stressors such as sun exposure and pollution, increases circulation to provide an oxygen boost for improved cell turnover, and exhibits anti-inflammatory properties that reduce irritation while stimulating collagen production.

In addition, niacin’s contribution to liver health is noteworthy, as the liver plays a critical role in detoxification, thereby promoting healthier-looking skin. In addition, niacin, when taken in the form of supplements such as NR, possesses properties essential for the establishment of new hair follicles, resulting in thicker and healthier hair growth, making it an important factor in addressing hair thinning issues.

Green Tea Extract, a concentrated form of the active compounds found in green tea leaves, offers numerous potential anti-aging benefits. Rich in antioxidants and polyphenols, it has been associated with reduced risk of cancer and heart disease, improved cognitive function, digestive health, bone strength, improved metabolism, and potentially increased longevity. The polyphenols, particularly catechins, found in green tea extract scavenge free radicals, preventing oxidative damage and reducing signs of aging.

In addition, catechins may protect against UVB radiation damage, which contributes to aging symptoms such as wrinkles, sagging skin, and discoloration. Notably, green tea polyphenols exhibit remarkable anti-inflammatory properties, potentially reducing inflammation associated with age-related conditions such as arthritis. In addition, green tea’s neuroprotective effects are being studied, suggesting that it may support better brain health by protecting neurons from oxidative stress.

Used in a variety of ways, silicon dioxide helps to enhance the anti-aging effects of skin care. Its effectiveness lies in reducing the appearance of wrinkles and fine lines, while protecting the skin from future damage and maintaining a youthful appearance. Amorphous Silica, the dominant form of silicon dioxide used in skin care products, forms a protective film on the skin’s surface. This film not only retains moisture, but also acts as a barrier against harsh external irritants such as dirt, oil, smog and pollutants that accelerate premature aging.

In addition, the silica particles have remarkable antioxidant properties that fight the signs of aging on contact with the skin. These antioxidants effectively neutralize existing free radicals on the skin’s surface, preventing damage to healthy cells. The result is a more harmonious complexion, with wrinkles and discolorations caused by sun damage or acne scars gradually diminishing over time.

Are NR supplements safe to take?

The safety of NR supplements is currently under investigation. In the short term, these supplements appear to be generally safe and well tolerated. However, it’s worth noting that, similar to other forms of vitamin B, certain side effects such as flushing and digestive problems may occur with the use of nicotinamide riboside (NR) and nicotinamide mononucleotide (NMN), although these side effects are rare and usually mild in nature.

At present, there is a lack of long-term studies examining the safety of NR and NMN. While the supplement industry often promotes NAD+ as a potential fountain of youth, cancer researchers have demonstrated success in inhibiting tumor growth by limiting NAD+ availability in patients.

It remains plausible that NAD+ could delay the onset of age-related conditions while potentially facilitating the growth of cancer cells in the body. Given the current uncertainties, it is prudent to approach NR supplementation with caution. It is wise to consult with a health care professional before beginning NR supplementation, especially if there is a personal or family history of cancer.

Possible Side Effects of Taking NR Supplements

While NR supplements are generally safe, high doses of these NAD+ precursors may cause some adverse effects, including

  • Fatigue
  • diarrhea
  • Nausea
  • upset stomach
  • Mild headache

It is advisable to consult with a healthcare professional before starting any supplement, especially if you have any underlying medical conditions. NR supplements may interact with prescription medications, and professional guidance is necessary to ensure safety and efficacy.

Methods to Increase NAD+ Levels Naturally

In addition to supplementation, there are natural ways to boost NAD+ levels as recommended by longevity experts:

  • Consider intermittent fasting or maintaining a low-calorie diet, as these practices may help stabilize NAD+ levels without directly increasing them.
  • Engage in regular exercise, which may not directly increase NAD+ levels but can stabilize ATP production, the primary source of cellular energy.
  • Include NMN-rich foods in your diet.
  • Consume foods rich in vitamin B3, such as milk, whole grains, fish, and yeast.

Frequently Asked Questions (FAQ)

What health benefits can NR supplements provide?
NR supplements provide a number of health benefits, including support for cellular health and the aging process. They play a critical role in cellular energy production and contribute to DNA repair.

Since NAD+ levels naturally decline with age, maintaining healthy levels is important for maintaining cognitive function and promoting healthy aging. NR supplements can aid in cellular repair and protect against damage caused by oxidative stress.

Are NR supplements considered safe?
Yes, NAD+ supplements, including NMN and NR, are generally safe and well tolerated. There are no significant adverse effects when taken in optimal doses.

Can NR Boosters cause any side effects?
Although side effects may vary depending on the specific NR Booster used, they are generally mild and temporary. Common side effects include headaches, fatigue, gastrointestinal upset, and skin irritation, which usually subside within a few days of starting supplementation.

In rare cases, lower quality products can cause more serious side effects such as liver damage and allergic reactions. It is important to note that such serious side effects are typically associated with products that do not use clinically proven ingredients.

Do NR supplements really work?
In fact, clinical studies and user feedback indicate the efficacy of NR supplements. However, individual responses to supplements can vary, and benefits may manifest over time or be detected by blood tests.

Are NR supplements different from NMN supplements?
NR supplements include NMN, NAD+ and other precursor molecules. Some supplements contain NR molecules as well. While they provide similar benefits, NR supplements and NMN supplements differ in size and absorption rate.

How can NAD+ levels be increased naturally?
NAD+ levels naturally decline with age, but there are ways to support and prevent a rapid decline. Eating a healthy diet rich in fruits, vegetables, and whole grains provides antioxidants that protect cells and reduce inflammation.

Regular exercise, including moderate exercise and high-intensity interval training, increases blood flow and cellular energy production, thereby boosting NAD+ levels. Getting enough sleep is also important, as sleep deprivation can lead to decreased NAD+ levels.

Which Brand Offers the Best NR Supplements?
While there is no one-size-fits-all answer, our market research suggests that GenF20 NR stands out as an excellent NR supplement for promoting healthy aging. This brand offers high purity, bioavailable supplements in safe doses.


In summary, maintaining adequate levels of nicotinamide riboside (NR) is critical for optimal cellular function. As we age, NAD+ levels naturally decline, leading to various age-related problems. While there are natural methods to increase NAD+ levels, there is also the option of using nicotinamide riboside (NR) supplements.

Supplementation with NR can result in increased energy levels. In addition, nicotinamide riboside supplements offer potential health benefits, including the reversal of age-related conditions and support for graceful aging. It is important to note that individual experiences may vary, and it is advisable to consult with a healthcare professional before incorporating any supplements into your routine.


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