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Fisetin is recognized as one of the most important compounds for postponing the aging process and extending healthspan (the healthy years of our life, free from age-related illnesses). This little-known flavonoid has been clinically proven to improve cognitive function, eliminate senescent (zombie) cells, and elevate cardiovascular and metabolic health.
While you can find fisetin in certain foods, the amount is too minuscule for advanced health-related benefits. As a result, we must look into fisetin supplementation to boost overall health and extend our healthspan.
In this article, we will review in detail what we consider the three best fisetin supplements currently on the market. These include:
- GenuinePurity Fisetin – The Best Supplement with Liposomal Delivery
- ProHealth Pure – The Best Fisetin Supplement for Intermittent High-Dose Use
- HumanX Fisetin – The Best Supplement with the Highest Dosage
A little further down, we’ll get into the exact formulation of these supplements, why you should consider these over their inferior counterparts, and where to safely purchase them online. But first, let’s look a bit into who will benefit the most from a fisetin supplement.
| Best Product |
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 |
 |
 |
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| Product | HumanX |
ProHealth |
GenuinePurity |
| Effects | ✓ Supports longevity ✓ Brain health ✓ Anti-Aging |
✓ Supports longevity ✓ Brain health ✓ Cellular health |
✓ Cognitive function ✓ Reduces inflammation ✓ Cellular damage |
| Side Effects |
✓ NO side effects | ✓ NO side effects | ✓ NO side effects |
| Content | 30 capsules | 60 capsules | 60 capsules |
| Dosage | 1 capsule | 1-2 capsules daily | 1 capsule daily |
| Enough for | 30 days | 30-60 days | 60 days |
| Price | 44.95 USD |
29.60 USD |
59.95 USD |
| Rating | ⭐⭐⭐⭐⭐ 5/5 |
⭐⭐⭐⭐⭐ 5/5 |
⭐⭐⭐⭐⭐ 5/5 |
 |
|
The Best Fisetin Supplement – Our Top 3 Picks
Let’s get into our detailed review of each of our top three picks for the best supplement. Each of these picks is a pure, 100% fisetin supplement. We stayed away from multi-ingredient supplements so that we could focus on only the best, most pure products. Let’s take a look.
#1 GenuinePurity – The Best Fisetin Supplement with Liposomal Delivery
- Enhances Cognitive Functions
- Helps Reduce Harmful Inflammation
- Protects Against Cellular Damage
- Price: $59.95
Coming in at the top of our list is GenuinePurity. We believe this to be the best fisetin supplement available. The GenuinePurity brand focuses solely on supplements that help to extend lifespan and healthspan. And we think they knocked it out of the park with GenuinePurity Fisetin.
From formulation to an advanced delivery system to the best product guarantee we’ve found, GenuinePurity has gone above and beyond in creating a quality supplement that should deliver as promised. Let’s take a closer look.
GenuinePurity Fisetin – What Sets it Apart
We chose GenuinePurity as the best fisetin supplement for many reasons. A few of the stand-outs are:
- Clinically Studied Dosage
- Purity of Fisetin
- Quality Manufacturing
- Extended Product Guarantee
- Advanced Liposomal Delivery
Let’s take a closer look at what makes these features so remarkable.
Clinically Studied Dosage
Numerous clinical studies have been conducted to understand the best fisetin dosage for health benefits. Dosages from 100mg per day up to 1500mg per day (and more) were studied.
Many studies concluded that more fisetin per day doesn’t necessarily equate to more benefits. Sometimes, the exact opposite turned out to be the case. Once larger dosages were introduced, benefits started to reach a point of diminishing returns.
In addition, when larger dosages were introduced, the body would often absorb what it needed and expel the rest as waste. So, if you’re paying for 1000mg of fisetin daily, you may only be absorbing and getting the benefits of a fraction of that amount.
GenuinePurity took these studies on dosages into account. So, instead of bombarding your body with massive amounts of fisetin, they formulated their product with a clinically studied dosage that will give you all of the benefits of fisetin supplementation without the waste and diminishing returns.
It turns out this dosage sweet spot starts at around 150mg per day with the aid of advanced absorption from Liposomal – GenuinePurity’s unique drug delivery system. This is the dosage of fisetin that GenuinePurity has decided to use in its formulation.
Purity of Fisetin
Not all of the fisetin in fisetin supplements is created equal. Fisetin can be added to a supplement as 100% pure, all the way down to as low as 10% pure. In our reviews, we found numerous fisetin supplements using low-quality fisetin that are unlikely to offer many health benefits.
Only quality supplements with high-purity fisetin added should be considered for supplementation. GenuinePurity markets their fisetin as NTL (not lower than) 90%. It should be noted, though, that the actual purity, based on the scientific certificate of authenticity, is nearly 100%.
Quality Manufacturing
GenuinePurity Fisetin is manufactured in an FDA-approved cGMP (current Good Manufacturing Practices) facility in the USA. This ensures the product is safe and effective.
Extended Product Guarantee
GenuinePurity Fisetin is so committed to ensuring you’re happy with its product that it offers one of the best refund policies we’ve seen. If you’re unhappy with your results for any reason, you have a full 97 days to return your open bottle and any unopened bottles you may have for a full refund of the purchase price, no questions asked.
Advanced Liposomal Delivery
GenuinePurity Fisetin’s advanced delivery system is one of the main reasons we consider it the best fisetin supplement on the market. Fisetin is notorious for having low bioavailability. This means that most of the fisetin you consume is degraded in the digestive tract before it can be absorbed.
GenuinePurity has solved this problem by encapsulating its fisetin payload with liposomal technology. While the process is technical, basically, this just means that the fisetin in GenuinePurity is surrounded by lipid molecules.
These lipid molecules protect the fisetin from stomach acids, delivering it safely to the small intestines where it can be absorbed. GenuinePurity is the only fisetin supplement we reviewed that incorporates this advanced delivery method.
GenuinePurity Fisetin – Product Features
Other features that GenuinePurity offers that we appreciate are:
- GMO-Free
- All Organic
- Vegan-Friendly
- 3rd Party Certificate of Authenticity
- Free from Gluten, Sugar, Dairy, Eggs, and Wheat
Our research led us to conclude that GenuinePurity created the best fisetin supplement on the market. It offers a scientifically studied dose of at least 90% pure fisetin without any unwanted ingredients or fillers.
GenuinePurity Fisetin – How to Take
The manufacturer recommends taking 1 GenuinePurity capsule daily with a meal and 8oz of water.
GenuinePurity Fisetin – Pricing
We’re kind of surprised that the price of GenuinePurity came in as low as it did. Especially considering the cost of its liposomal delivery system. The price for this quality supplement is:
- 1 Bottle = 2 Month Supply – $59.95 ($1.00 per Day)
- 3 Bottles = 6 Month Supply – $159.95 (0.89 per Day)
- 6 Bottles = 12 Month Supply – $259.95 ($0.72 per Day)
In addition to its bulk pricing, GenuinePurity offers free shipping in the continental USA on all of its products. And with its 97-day money-back guarantee on the purchase price, you really have nothing to lose on this purchase.
GenuinePurity Fisetin – Where to Buy
We suggest purchasing GenuinePurity Fisetin directly from the manufacturer to ensure you get an authentic product and so you can take advantage of the bulk pricing and guarantee.
#2 ProHealth Pure – The Best Fisetin Supplement for Intermittent High-Dose Use
- Supports Longevity
- Promotes Brain Health
- Enhances Cellular Health
- Price: $29.60
ProHealth Pure Fisetin comes in at a respectable second on our list of the best fisetin supplements. ProHealth is a family-owned business that has been in the anti-aging space for over 36 years. Any supplement company in business for that long has got to be doing something right.
We consider ProHealth Pure the best fisetin supplement for anyone interested in the Senolytic Protocol. This protocol involves taking high doses of fisetin over the short term. According to Dr. Nick Bitz, the Chief Science Officer at ProHealth, this is the quickest way to remove senescent (zombie) cells from the body.
ProHealth Pure Fisetin – What Sets it Apart
What sets ProHealth Pure apart from the competition is its dual approach to supplementation. It can be taken as a low-dose daily supplement or as a high-dose intermittently.
If you’re just starting your fisetin-supplementing journey and are nervous about taking higher dosages, ProHealth Pure is a great start. Additionally, if you’re looking for the best fisetin supplement for intermittent, high-dose use, ProHealth Pure might be the best for your needs.
ProHealth Pure Fisetin – Product Features
Apart from its advanced senescent-cell-removing method of supplementation, there are some other features ProHealth Pure offers:
- Triple 3rd Party Tested for Potency and Safety
- Manufactured in the USA in a cGMP Facility
- Formulated with 250mg of 98% Pure Fisetin
- Free from GMO, Dairy, Egg, Soy, Wheat, & Gluten
Since ProHealth Pure Fisetin has no advanced delivery system for extra absorption, like liposomal, it falls on the lower end of the scientifically studied range of dosage. This is a solid dosage for anyone just starting out on fisetin supplementation or who wants to use multiple low-dosage pills for intermittent use.
ProHealth Pure Fisetin – How to Take
There are two methods of supplementation that ProHealth recommends for its fisetin product:
- Low-Dose, Daily Supplementation – 1 capsule daily with food and water.
- High-Dose, Intermittent Supplementation – 6 capsules daily with food and water for 5 days. Take 4 weeks off and repeat.
ProHealth Pure is the best fisetin supplement for anyone focused on quickly removing senescent cells from their body through the Senolytic Protocol.
ProHealth Pure Fisetin – Pricing
The price of ProHealth Pure will run you:
- 1 Bottle = 2 Month Supply – $55.49 ($0.93 per Day)
The price works out to be the same monthly, regardless of which method of supplementation you go with. There are 60 pills per bottle, so one bottle, going the low-dose daily method, will last you 2 months.
If you go with the high-dose, intermittent method of supplementation, you’re still taking 30 pills per month; you’re just doing so over the course of 5 days instead of 30. The price per month remains the same.
ProHealth Pure Fisetin – Where to Buy
You can purchase ProHealth Pure Fisetin directly from the manufacturer. You’ll get free delivery within the continental US and a 10% discount with recurring orders.
#3 HumanX – The Best Fisetin Supplement with the Highest Dosage
- Supports Longevity
- Promotes Brain Health
- Anti-Aging
- Price: $44.95
Coming in at #3 on our list is HumanX Fisetin. HumanX is a USA-based manufacturer of “clean supplements”. Their supplements are formulated only with quality, scientifically backed ingredients and are free from fillers, colors, sweeteners, and additives.
HumanX’s team of doctors, scientists, and researchers have created what we think is the best fisetin supplement on the market, with the highest dosages of pure fisetin and nothing else.
HumanX Fisetin – What Sets it Apart
Earlier, we discussed that higher dosages of fisetin aren’t always the best. There is a scientifically studied range of milligrams per day that seems to offer the best results. Since GenuinePurity offers liposomal technology, they were able to offer a lower dose of fisetin.
In place of liposomal technology, HumanX has opted to go with a much larger dose of fisetin in its formulation. Let’s look at its formulation and what else sets HumanX apart from the other fisetin supplements on the market:
High Dosage – HumanX has one of the highest dosages we’ve seen, 500mg of fisetin in each serving. While HumanX doesn’t use Liposomal in its formula, at 500mg, even if the body only absorbs a portion of the active ingredients inside, you should be able to achieve adequate outcomes.
High Purity – HumanX isn’t messing around with low-quality fisetin. They’re using 98% pure fisetin in its formula.
Quality Manufacturing – HumanX is manufactured in the USA in a cGMP-compliant facility.
HumanX might be the best fisetin supplement for your needs if you’re looking for a high-quality, high-dosage fisetin supplement.
HumanX Fisetin – Product Features
Aside from its fisetin purity and high dose, there are some other features that make HumanX stand out. These include:
- Non-GMO
- All-Vegan
- No Artificial Colors or Flavor
- Gluten, Soy, & Shellfish Free
- 30-Day Money-Back Guarantee
HumanX offers a quality fisetin supplement that is free from the fillers and additives that some inferior products use.
HumanX Fisetin – How to Take
HumanX recommends taking 1 capsule daily with water and your morning meal.
HumanX Fisetin – Pricing
High doses of 98% pure fisetin don’t come cheap. If you’re looking for a quality product, you’re going to be paying a little more. As a result, the price of HumanX is:
- 1 Bottle = 1 Month Supply – $44.95 ($1.50 per Day)
Delivery is free within the lower 48 states. While bulk pricing isn’t available, HumanX does offer subscription-based pricing. If you sign up for recurring monthly orders, you will receive a 10% discount on each order.
HumanX Fisetin – Where to Buy
HumanX can be purchased easily and conveniently directly from Amazon.
A Side-by-Side Comparison of the 3 Best Fisetin Supplements
Let’s look at a side-by-side comparison of the fisetin supplements in our review. This should help you better understand which is the best fisetin supplement for your specific needs.
| HumanX |
ProHealth |
GenuinePurity | |
| Fisetin Purity | 98 % |
98 % |
90 - 100 %* |
| Daily Dosage |
500 mg | 250 mg | 150 mg |
| Advanced Delivery | No | No | Liposomal |
| Vegan | Yes | Yes | Yes |
| Made in the USA | Yes | Yes | Yes |
| 3rd Party Testing | Unknown | Yes | Yes |
| Pills per Day | 1 | 1 or 6** | 1 |
| Bulk Discounts | No | No | Yes |
| Free Shipping | Yes | Yes | Yes |
| Product Guarantee | 30 Days | Unknown | 97 Days |
| Where To Buy | |
|
*The marketed purity is 90%. The actual purity based on the 3rd Party CoA is 100%.
**1 pill daily for low-dose supplementation or 6 pills daily for high-dose intermittent supplementation.
When looking at these three quality fisetin supplements side-by-side, it’s clear that GenuinPurity Fisetin comes out as the best fisetin supplement overall. It offers an advanced delivery system, a generous money-back guarantee, and, if purchased in bulk, is the least expensive option on our list.
Who Can Benefit From Taking the Best Fisetin Supplement?
Generally speaking, anyone concerned about the degenerative effects of aging should look into fisetin supplementation. Whether you’re in your 50s to 60s and already feeling the effects, or you’re in your 30s or 40s, hoping to postpone the effects of aging as long as you can.
By supporting cellular regeneration and reducing oxidative damage, fisetin can enhance overall health and potentially slow down the aging process. This helps to promote a longer lifespan, as well as keep us healthy and happy during the later years of our lives.
Specific Benefits of Fisetin Supplementation
Specifically speaking, the following people would benefit most from finding the best fisetin supplement. Anyone who is:
- Concerned about Cognitive Health – As we age, our mental acuity is one of the first things to go. Fisetin supplementation can postpone and even help preserve a healthy cognitive state. Fisetin protects the brain’s cells, helping preserve brain health, improve memory, and enhance cognitive abilities.
- Interested in Improving Heart Health – Fisetin has been clinically proven to support the overall health of the circulatory system by improving blood vessel function and protecting against oxidative damage.
- Longing for Younger-Looking Skin – Fisetin has powerful antioxidant properties that help keep skin cells healthy, improve skin elasticity, and reduce the appearance of fine lines and wrinkles.
- Concerned about Injury – Fisetin has both anti-inflammatory and antioxidant properties. This is especially helpful for athletes concerned about post-workout swelling and muscle fatigue, which could lead to injury.
- Concerned About Liver & Kidney Function – If you are, or were, a heavy drinker and are concerned about the damage done to internal organs, fisetin supplementation could offer certain benefits. Fisetin may support liver and kidney health by assisting in cellular regeneration, supporting the liver’s detoxification efforts, and helping to minimize oxidative damage caused by alcohol consumption.
- Interested in the Removal of Senescent Cells – One of the greatest benefits of fisetin supplementation is its ability to flush senescent (zombie) cells from the body. These dead, dying, or decayed cells are responsible for weakening the immune system and increasing the risk of age-related medical issues.
- Looking for an Elite General Health Supplement – While fisetin is able to help reduce and even delay certain age-related declines in bodily structure and function, like those above, it’s also a solid general health supplement for anyone interested in improving their overall well-being.
Anyone, young or old, can benefit greatly from fisetin supplementation.
Who Should Not Be Taking Fisetin Supplements
While fisetin supplementation is generally considered safe for most people, there are some who may want to reconsider fisetin supplementation. Those include:
- Women who are pregnant or nursing.
- Anyone taking blood thinning medication.
- Anyone with blood clotting issues.
- Children under the age of 18.
- Anyone with an allergy to fisetin sources (strawberries, apples, cucumbers, etc.).
- Anyone with low blood pressure.
- Anyone with severe gastrointestinal issues.
If you’re unsure if fisetin supplementation is right for you, please consult your physician for a professional recommendation.
Other Natural Sources of Fisetin
Fisetin is a naturally occurring compound in many of the foods we already eat. Some foods that are high in fisetin include:
- Strawberries (with the highest concentration of fisetin of any natural food source)
- Apples
- Onions
- Cucumbers
- Kiwi Fruit
- Grapes
- Mangoes
- Tomatoes
- Peaches
While eating strawberries is a natural way to introduce fisetin to your diet, you’d have to eat dozens of strawberries per day, every day, to get even close to the minimal clinically studied dosage of fisetin needed to make any difference.
In addition, since fisetin is prone to degradation before absorption, most of the fisetin in the strawberries would be degraded in the digestive tract before it had a chance to be absorbed.
If you’re looking for the serious anti-aging benefits of fisetin, you will need to consider fisetin supplementation.
Is it Time to Buy the Best Fisetin Supplement for Your Needs?
If you’re starting to feel as old as your years, it might be time to start taking the best fisetin supplement you can find. The fisetin in these supplements has been clinically proven to help you feel younger by reducing the dead and damaged cells in your body.
The only thing left to do is decide which fisetin supplement is best for your needs. As a recap, we think:
- GenuinePurity is the best fisetin supplement overall based on its advanced delivery and clinically studied dosage. Not to mention, it’s the least expensive if bought in bulk.
- ProHealth Pure Fisetin is the best supplement for anyone interested in high-dosage intermittent fasting.
- HumanX is the best fisetin supplement for anyone looking for a higher-than-average daily dosage.
Today is your day. This is the day you start to take control of your metabolic, cognitive, and cardiovascular health. Any of these supplements should help make you feel like a younger, healthier version of yourself within a few short weeks. You deserve it!
Frequently Asked Questions
Are there any possible side effects associated with fisetin supplements?
Fisetin supplements are generally considered safe when taken as directed. However, some people may experience mild side effects, including gastrointestinal upset, headache, or dizziness. It is advisable to consult a health care professional before beginning any dietary supplement program.
Can fisetin supplements help with cognitive decline associated with aging?
Some studies suggest that fisetin may provide cognitive benefits, such as improving memory and reducing age-related cognitive decline. However, more research is needed to fully understand its effects on cognitive function.
What is the expected time frame for experiencing the benefits of fisetin?
The time it takes to experience the benefits of fisetin supplements may vary from person to person. Some studies suggest that certain cellular health markers may show improvement within a few weeks. Manufacturers generally recommend continuous daily use for several months to achieve optimal health results.
What are the benefits of liposomal fisetin supplements?
Liposomal supplements are designed to increase the absorption and bioavailability of fisetin in the body. This improved absorption may enhance the benefits, including antioxidant and anti-inflammatory effects, as well as potential cognitive and cardiovascular benefits.
What is the recommended daily dose of fisetin supplements?
The recommended daily dosage of fisetin supplements varies by brand and formulation. It is important to follow the manufacturer’s guidelines and consult with a health care professional before starting any supplement routine.
Sources
- National Center for Biotechnology Information. “Fisetin alleviates oxidative stress after traumatic brain injury via the Nrf2-ARE pathway.” Read Article.
- National Center for Biotechnology Information. “Exploring the anti-aging effects of fisetin in telomerase-deficient progeria mouse model.” Read Article.
- National Center for Biotechnology Information. “Fisetin is a senotherapeutic that extends health and lifespan.” Read Article.
- National Center for Biotechnology Information. “Fisetin ameliorates cognitive impairment by activating mitophagy and suppressing neuroinflammation in rats with sepsis-associated encephalopathy.” Read Article.
